Enzymatic and chemo-enzymatic synthesis of carbohydrates
نویسندگان
چکیده
منابع مشابه
Enzymatic and chemo-enzymatic synthesis of carbohydrates
Carbohydrate-mediated biochemical recognition processes are potential targets for drug development. The synthesis of complex carbohydrates and related structures, however, has been a difficult task, especially from practical point of view. New solutionand solidphase methods based on enzymatic and a combined enzymatic and chemical procedure have recently been developed for the practical synthesi...
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A cleaner and greener method has been developed and used to synthesize 14 different functionalized oligomer derivatives of glycerol in moderate 29%-39% yields over three steps. After successive regioselective enzymatic acylation of the primary hydroxyl groups, etherification or esterification of the secondary hydroxyl groups and chemoselective enzymatic saponification, the target compounds can ...
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Divalent or multivalent molecules often show enhanced biological activity relative to the simple monomeric units. Here we present enzymatically and chemically prepared dimers of the flavonolignans silybin and 2,3-dehydrosilybin. Their electrochemical behavior was studied by in situ and ex situ square wave voltammetry. The oxidation of monomers and dimers was similar, but adsorption onto the ele...
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A short overview is given of new developments in the chemo-enzymatic synthesis of amino acids. Amino acid resolution procedures based on stereoselective enzymatic hydrolysis of amino acid amides have been developed. Two enzymes, an aminopeptidase from Pseudomonas putida and an amidase from Hycobacterium neoaurum have been purified to homogeneity. In addition, methods for the stereoselective syn...
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Moving away from crude oil to renewable resources for the production of a wide range of compounds is a challenge for future generations. To overcome this, the use of lignocellulose as substrate can contribute to drastically reduce the consumption of crude oil. In this study, sugars from lignocellulose were used as a starting material for the enzymatic synthesis of surface-active sugar esters. T...
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ژورنال
عنوان ژورنال: Pure and Applied Chemistry
سال: 1995
ISSN: 1365-3075,0033-4545
DOI: 10.1351/pac199567101609